ARISTOTLE
Multiple Disease Signatures
Liew CC, Ma J, Tang HC, Zheng R, Dempsey AA. The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool. J Lab Clin Med. 2006 Mar;147(3):126-32. doi: 10.1016/j.lab.2005.10.005. PMID: 16503242.
Mohr S, Liew CC. The peripheral-blood transcriptome: new insights into disease and risk assessment. Trends Mol Med. 2007 Oct;13(10):422-32. doi: 10.1016/j.molmed.2007.08.003. Epub 2007 Oct 4. PMID: 17919976.
Chao S, Marshall WK, Khettabi FE, Tang H, Liew CC, Mok S. Multiple diseases discriminated by quantitation of blood transcriptome. Internet Journal of Genomics and Proteomics 2010 vol. 6, no. 1.
Novak DJ, Liew GJ, Liew CC. GeneNews Limited: bringing the blood transcriptome to personalized medicine. Pharmacogenomics. 2012 Mar;13(4):381-5. doi: 10.2217/pgs.12.12. PMID: 22379995.
Chao S, Cheng C, Liew CC. Mining the Dynamic Genome: A Method for Identifying Multiple Disease Signatures Using Quantitative RNA Expression Analysis of a Single Blood Sample. Microarrays (Basel). 2015 Dec 10;4(4):671-89. doi: 10.3390/microarrays4040671. PMID: 27600246; PMCID: PMC4996407.
Chao J, Chaban G, Cheng C, Piarar S, Liew CC. Application of a Blood-based Dynamic Genome Signature: How MAS5/RMA/PLIER Normalization Batches Affect Measured Gene Expression Profiling Stability in Clinical Diagnosis. 2018 J Clin Exp Pathol, 8(333), pp.2161-0681.
Dempsey AA, Chao S, Stamatiou D, Pilcz T, Ying J, Burakoff R. Aristotle: A single blood test for pan-cancer screening. Journal of Clinical Oncology 2020 38:15_suppl, e15037-e15037.
Disease Specific Signatures
Liver/Nasopharyngeal/Prostate/Urinary Bladder Cancer
Osman I, Bajorin DF, Sun TT, Zhong H, Douglas D, Scattergood J, Zheng R, Han M, Marshall KW, Liew CC. Novel blood biomarkers of human urinary bladder cancer. Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3374-80. doi: 10.1158/1078-0432.CCR-05-2081. PMID: 16740760.
Liong ML, Lim CR, Yang H, Chao S, Bong CW, Leong WS, Das PK, Loh CS, Lau BE, Yu CG, Ooi EJ, Nam RK, Allen PD, Steele GS, Wassmann K, Richie JP, Liew CC. Blood-based biomarkers of aggressive prostate cancer. PLoS One. 2012;7(9):e45802. doi: 10.1371/journal.pone.0045802. Epub 2012 Sep 28. PMID: 23071848; PMCID: PMC3461021.
Zaatar AM, Lim CR, Bong CW, Lee MM, Ooi JJ, Suria D, Raman R, Chao S, Yang H, Neoh SB, Liew CC. Whole blood transcriptome correlates with treatment response in nasopharyngeal carcinoma. J Exp Clin Cancer Res. 2012 Sep 17;31(1):76. doi: 10.1186/1756-9966-31-76. PMID: 22986368; PMCID: PMC3504566.
Liew CC, Omar H, Lim CR, Bong CW, Ooi EJ, Lee MM, Yu CG, Tan SS, Hassan MR, Menon J, Muthukaruppan R. Blood signatures for early liver cancer detection in patients with chronic hepatitis B. Journal of Clinical Oncology 2012 30:15_suppl, 4106-4106.
Omar H, Lim CR, Chao S, Lee MM, Bong CW, Ooi EJ, Yu CG, Tan SS, Abu Hassan MR, Menon J, Muthukaruppan R, Singh M, Nik Abdullah NA, Ooi BP, Ding RP, Low EJ, Tan F, Novak D, Harris DF, Yang H, Merican I, Liew CC. Blood gene signature for early hepatocellular carcinoma detection in patients with chronic hepatitis B. J Clin Gastroenterol. 2015 Feb;49(2):150-7. doi: 10.1097/MCG.0000000000000112. PMID: 25569223.
Colorectal Cancer (See ColonSentry References)
Crohn’s and Ulcerative Colitis
Burakoff R, Hande S, Ma J, Banks PA, Friedman S, Makrauer F, Liew CC. Differential regulation of peripheral leukocyte genes in patients with active Crohn's disease and Crohn's disease in remission. J Clin Gastroenterol. 2010 Feb;44(2):120-6. doi: 10.1097/MCG.0b013e3181a9ef53. PMID: 19826276.
Burakoff R, Chao S, Perencevich M, Ying J, Friedman S, Makrauer F, Odze R, Khurana H, Liew CC. Blood-based biomarkers can differentiate ulcerative colitis from Crohn's disease and noninflammatory diarrhea. Inflamm Bowel Dis. 2011 Aug;17(8):1719-25. doi: 10.1002/ibd.21574. Epub 2011 Jan 6. PMID: 21744426.
Barnes EL, Liew CC, Chao S, Burakoff R. Use of blood based biomarkers in the evaluation of Crohn's disease and ulcerative colitis. World J Gastrointest Endosc. 2015 Nov 25;7(17):1233-7. doi: 10.4253/wjge.v7.i17.1233. PMID: 26634038; PMCID: PMC4658602.
Burakoff R, Pabby V, Onyewadume L, Odze R, Adackapara C, Wang W, Friedman S, Hamilton M, Korzenik J, Levine J, Makrauer F, Cheng C, Smith HC, Liew CC, Chao S. Blood-based biomarkers used to predict disease activity in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 2015 May;21(5):1132-40. doi: 10.1097/MIB.0000000000000340. PMID: 25895006.
Heart Failure/Cardiovascular Disease
Ma J, Liew CC. Gene profiling identifies secreted protein transcripts from peripheral blood cells in coronary artery disease. J Mol Cell Cardiol. 2003 Aug;35(8):993-8. doi: 10.1016/s0022-2828(03)00179-2. PMID: 12878486.
Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC. Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. Atherosclerosis. 2007 Mar;191(1):63-72. doi: 10.1016/j.atherosclerosis.2006.05.032. Epub 2006 Jun 30. PMID: 16806233.
Liew CC. Expressed genome molecular signatures of heart failure. Clin Chem Lab Med. 2005;43(5):462-9. doi: 10.1515/CCLM.2005.084. PMID: 15899667.
Vanburen P, Ma J, Chao S, Mueller E, Schneider DJ, Liew CC. Blood gene expression signatures associate with heart failure outcomes. Physiol Genomics. 2011 Apr 27;43(8):392-7. doi: 10.1152/physiolgenomics.00175.2010. Epub 2011 Jan 25. PMID: 21266504; PMCID: PMC3092336.
Osteoarthritis
Zhang H, Marshall KW, Tang H, Hwang DM, Lee M, Liew CC. Profiling genes expressed in human fetal cartilage using 13,155 expressed sequence tags. Osteoarthritis Cartilage. 2003 May;11(5):309-19. doi: 10.1016/s1063-4584(03)00032-3. PMID: 12744936.
Marshall KW, Zhang H, Yager TD, Nossova N, Dempsey A, Zheng R, Han M, Tang H, Chao S, Liew CC. Blood-based biomarkers for detecting mild osteoarthritis in the human knee. Osteoarthritis Cartilage. 2005 Oct;13(10):861-71. doi: 10.1016/j.joca.2005.06.002. PMID: 16139532.
Schizophrenia/Mental Health
Tsuang MT, Nossova N, Yager T, Tsuang MM, Guo SC, Shyu KG, Glatt SJ, Liew CC. Assessing the validity of blood-based gene expression profiles for the classification of schizophrenia and bipolar disorder: a preliminary report. Am J Med Genet B Neuropsychiatr Genet. 2005 Feb 5;133B(1):1-5. doi: 10.1002/ajmg.b.30161. PMID: 15645418.
Glatt SJ, Stone WS, Nossova N, Liew CC, Seidman LJ, Tsuang MT. Similarities and differences in peripheral blood gene-expression signatures of individuals with schizophrenia and their first-degree biological relatives. Am J Med Genet B Neuropsychiatr Genet. 2011 Dec;156B(8):869-87. doi: 10.1002/ajmg.b.31239. Epub 2011 Oct 3. PMID: 21972136; PMCID: PMC3213682.
Mellon SH, Wolkowitz OM, Schonemann MD, Epel ES, Rosser R, Burke HB, Mahan L, Reus VI, Stamatiou D, Liew CC, Cole SW. Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment. Transl Psychiatry. 2016 May 24;6(5):e821. doi: 10.1038/tp.2016.79. P
Liew CC, Ma J, Tang HC, Zheng R, Dempsey AA. The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool. J Lab Clin Med. 2006 Mar;147(3):126-32. doi: 10.1016/j.lab.2005.10.005. PMID: 16503242.
Mohr S, Liew CC. The peripheral-blood transcriptome: new insights into disease and risk assessment. Trends Mol Med. 2007 Oct;13(10):422-32. doi: 10.1016/j.molmed.2007.08.003. Epub 2007 Oct 4. PMID: 17919976.
Chao S, Marshall WK, Khettabi FE, Tang H, Liew CC, Mok S. Multiple diseases discriminated by quantitation of blood transcriptome. Internet Journal of Genomics and Proteomics 2010 vol. 6, no. 1.
Novak DJ, Liew GJ, Liew CC. GeneNews Limited: bringing the blood transcriptome to personalized medicine. Pharmacogenomics. 2012 Mar;13(4):381-5. doi: 10.2217/pgs.12.12. PMID: 22379995.
Chao S, Cheng C, Liew CC. Mining the Dynamic Genome: A Method for Identifying Multiple Disease Signatures Using Quantitative RNA Expression Analysis of a Single Blood Sample. Microarrays (Basel). 2015 Dec 10;4(4):671-89. doi: 10.3390/microarrays4040671. PMID: 27600246; PMCID: PMC4996407.
Chao J, Chaban G, Cheng C, Piarar S, Liew CC. Application of a Blood-based Dynamic Genome Signature: How MAS5/RMA/PLIER Normalization Batches Affect Measured Gene Expression Profiling Stability in Clinical Diagnosis. 2018 J Clin Exp Pathol, 8(333), pp.2161-0681.
Dempsey AA, Chao S, Stamatiou D, Pilcz T, Ying J, Burakoff R. Aristotle: A single blood test for pan-cancer screening. Journal of Clinical Oncology 2020 38:15_suppl, e15037-e15037.
Disease Specific Signatures
Liver/Nasopharyngeal/Prostate/Urinary Bladder Cancer
Osman I, Bajorin DF, Sun TT, Zhong H, Douglas D, Scattergood J, Zheng R, Han M, Marshall KW, Liew CC. Novel blood biomarkers of human urinary bladder cancer. Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3374-80. doi: 10.1158/1078-0432.CCR-05-2081. PMID: 16740760.
Liong ML, Lim CR, Yang H, Chao S, Bong CW, Leong WS, Das PK, Loh CS, Lau BE, Yu CG, Ooi EJ, Nam RK, Allen PD, Steele GS, Wassmann K, Richie JP, Liew CC. Blood-based biomarkers of aggressive prostate cancer. PLoS One. 2012;7(9):e45802. doi: 10.1371/journal.pone.0045802. Epub 2012 Sep 28. PMID: 23071848; PMCID: PMC3461021.
Zaatar AM, Lim CR, Bong CW, Lee MM, Ooi JJ, Suria D, Raman R, Chao S, Yang H, Neoh SB, Liew CC. Whole blood transcriptome correlates with treatment response in nasopharyngeal carcinoma. J Exp Clin Cancer Res. 2012 Sep 17;31(1):76. doi: 10.1186/1756-9966-31-76. PMID: 22986368; PMCID: PMC3504566.
Liew CC, Omar H, Lim CR, Bong CW, Ooi EJ, Lee MM, Yu CG, Tan SS, Hassan MR, Menon J, Muthukaruppan R. Blood signatures for early liver cancer detection in patients with chronic hepatitis B. Journal of Clinical Oncology 2012 30:15_suppl, 4106-4106.
Omar H, Lim CR, Chao S, Lee MM, Bong CW, Ooi EJ, Yu CG, Tan SS, Abu Hassan MR, Menon J, Muthukaruppan R, Singh M, Nik Abdullah NA, Ooi BP, Ding RP, Low EJ, Tan F, Novak D, Harris DF, Yang H, Merican I, Liew CC. Blood gene signature for early hepatocellular carcinoma detection in patients with chronic hepatitis B. J Clin Gastroenterol. 2015 Feb;49(2):150-7. doi: 10.1097/MCG.0000000000000112. PMID: 25569223.
Colorectal Cancer (See ColonSentry References)
Crohn’s and Ulcerative Colitis
Burakoff R, Hande S, Ma J, Banks PA, Friedman S, Makrauer F, Liew CC. Differential regulation of peripheral leukocyte genes in patients with active Crohn's disease and Crohn's disease in remission. J Clin Gastroenterol. 2010 Feb;44(2):120-6. doi: 10.1097/MCG.0b013e3181a9ef53. PMID: 19826276.
Burakoff R, Chao S, Perencevich M, Ying J, Friedman S, Makrauer F, Odze R, Khurana H, Liew CC. Blood-based biomarkers can differentiate ulcerative colitis from Crohn's disease and noninflammatory diarrhea. Inflamm Bowel Dis. 2011 Aug;17(8):1719-25. doi: 10.1002/ibd.21574. Epub 2011 Jan 6. PMID: 21744426.
Barnes EL, Liew CC, Chao S, Burakoff R. Use of blood based biomarkers in the evaluation of Crohn's disease and ulcerative colitis. World J Gastrointest Endosc. 2015 Nov 25;7(17):1233-7. doi: 10.4253/wjge.v7.i17.1233. PMID: 26634038; PMCID: PMC4658602.
Burakoff R, Pabby V, Onyewadume L, Odze R, Adackapara C, Wang W, Friedman S, Hamilton M, Korzenik J, Levine J, Makrauer F, Cheng C, Smith HC, Liew CC, Chao S. Blood-based biomarkers used to predict disease activity in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 2015 May;21(5):1132-40. doi: 10.1097/MIB.0000000000000340. PMID: 25895006.
Heart Failure/Cardiovascular Disease
Ma J, Liew CC. Gene profiling identifies secreted protein transcripts from peripheral blood cells in coronary artery disease. J Mol Cell Cardiol. 2003 Aug;35(8):993-8. doi: 10.1016/s0022-2828(03)00179-2. PMID: 12878486.
Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC. Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. Atherosclerosis. 2007 Mar;191(1):63-72. doi: 10.1016/j.atherosclerosis.2006.05.032. Epub 2006 Jun 30. PMID: 16806233.
Liew CC. Expressed genome molecular signatures of heart failure. Clin Chem Lab Med. 2005;43(5):462-9. doi: 10.1515/CCLM.2005.084. PMID: 15899667.
Vanburen P, Ma J, Chao S, Mueller E, Schneider DJ, Liew CC. Blood gene expression signatures associate with heart failure outcomes. Physiol Genomics. 2011 Apr 27;43(8):392-7. doi: 10.1152/physiolgenomics.00175.2010. Epub 2011 Jan 25. PMID: 21266504; PMCID: PMC3092336.
Osteoarthritis
Zhang H, Marshall KW, Tang H, Hwang DM, Lee M, Liew CC. Profiling genes expressed in human fetal cartilage using 13,155 expressed sequence tags. Osteoarthritis Cartilage. 2003 May;11(5):309-19. doi: 10.1016/s1063-4584(03)00032-3. PMID: 12744936.
Marshall KW, Zhang H, Yager TD, Nossova N, Dempsey A, Zheng R, Han M, Tang H, Chao S, Liew CC. Blood-based biomarkers for detecting mild osteoarthritis in the human knee. Osteoarthritis Cartilage. 2005 Oct;13(10):861-71. doi: 10.1016/j.joca.2005.06.002. PMID: 16139532.
Schizophrenia/Mental Health
Tsuang MT, Nossova N, Yager T, Tsuang MM, Guo SC, Shyu KG, Glatt SJ, Liew CC. Assessing the validity of blood-based gene expression profiles for the classification of schizophrenia and bipolar disorder: a preliminary report. Am J Med Genet B Neuropsychiatr Genet. 2005 Feb 5;133B(1):1-5. doi: 10.1002/ajmg.b.30161. PMID: 15645418.
Glatt SJ, Stone WS, Nossova N, Liew CC, Seidman LJ, Tsuang MT. Similarities and differences in peripheral blood gene-expression signatures of individuals with schizophrenia and their first-degree biological relatives. Am J Med Genet B Neuropsychiatr Genet. 2011 Dec;156B(8):869-87. doi: 10.1002/ajmg.b.31239. Epub 2011 Oct 3. PMID: 21972136; PMCID: PMC3213682.
Mellon SH, Wolkowitz OM, Schonemann MD, Epel ES, Rosser R, Burke HB, Mahan L, Reus VI, Stamatiou D, Liew CC, Cole SW. Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment. Transl Psychiatry. 2016 May 24;6(5):e821. doi: 10.1038/tp.2016.79. P
