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ARISTOTLE

Multiple Disease Signatures

Liew CC, Ma J, Tang HC, Zheng R, Dempsey AA. The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool. J Lab Clin Med. 2006 Mar;147(3):126-32. doi: 10.1016/j.lab.2005.10.005. PMID: 16503242.

Mohr S, Liew CC. The peripheral-blood transcriptome: new insights into disease and risk assessment. Trends Mol Med. 2007 Oct;13(10):422-32. doi: 10.1016/j.molmed.2007.08.003. Epub 2007 Oct 4. PMID: 17919976.

Chao S, Marshall WK, Khettabi FE, Tang H, Liew CC, Mok S. Multiple diseases discriminated by quantitation of blood transcriptome. Internet Journal of Genomics and Proteomics 2010 vol. 6, no. 1.

Novak DJ, Liew GJ, Liew CC. GeneNews Limited: bringing the blood transcriptome to personalized medicine. Pharmacogenomics. 2012 Mar;13(4):381-5. doi: 10.2217/pgs.12.12. PMID: 22379995.

Chao S, Cheng C, Liew CC. Mining the Dynamic Genome: A Method for Identifying Multiple Disease Signatures Using Quantitative RNA Expression Analysis of a Single Blood Sample. Microarrays (Basel). 2015 Dec 10;4(4):671-89. doi: 10.3390/microarrays4040671. PMID: 27600246; PMCID: PMC4996407.

Chao J, Chaban G, Cheng C, Piarar S, Liew CC. Application of a Blood-based Dynamic Genome Signature: How MAS5/RMA/PLIER Normalization Batches Affect Measured Gene Expression Profiling Stability in Clinical Diagnosis. 2018 J Clin Exp Pathol, 8(333), pp.2161-0681.

Dempsey AA, Chao S, Stamatiou D, Pilcz T, Ying J, Burakoff R. Aristotle: A single blood test for pan-cancer screening. Journal of Clinical Oncology 2020 38:15_suppl, e15037-e15037.
 
Disease Specific Signatures
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Liver/Nasopharyngeal/Prostate/Urinary Bladder Cancer

Osman I, Bajorin DF, Sun TT, Zhong H, Douglas D, Scattergood J, Zheng R, Han M, Marshall KW, Liew CC. Novel blood biomarkers of human urinary bladder cancer. Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3374-80. doi: 10.1158/1078-0432.CCR-05-2081. PMID: 16740760.

Liong ML, Lim CR, Yang H, Chao S, Bong CW, Leong WS, Das PK, Loh CS, Lau BE, Yu CG, Ooi EJ, Nam RK, Allen PD, Steele GS, Wassmann K, Richie JP, Liew CC. Blood-based biomarkers of aggressive prostate cancer. PLoS One. 2012;7(9):e45802. doi: 10.1371/journal.pone.0045802. Epub 2012 Sep 28. PMID: 23071848; PMCID: PMC3461021.

Zaatar AM, Lim CR, Bong CW, Lee MM, Ooi JJ, Suria D, Raman R, Chao S, Yang H, Neoh SB, Liew CC. Whole blood transcriptome correlates with treatment response in nasopharyngeal carcinoma. J Exp Clin Cancer Res. 2012 Sep 17;31(1):76. doi: 10.1186/1756-9966-31-76. PMID: 22986368; PMCID: PMC3504566.
 
Liew CC, Omar H, Lim CR, Bong CW, Ooi EJ, Lee MM, Yu CG, Tan SS, Hassan MR, Menon J, Muthukaruppan R. Blood signatures for early liver cancer detection in patients with chronic hepatitis B. Journal of Clinical Oncology 2012 30:15_suppl, 4106-4106.

Omar H, Lim CR, Chao S, Lee MM, Bong CW, Ooi EJ, Yu CG, Tan SS, Abu Hassan MR, Menon J, Muthukaruppan R, Singh M, Nik Abdullah NA, Ooi BP, Ding RP, Low EJ, Tan F, Novak D, Harris DF, Yang H, Merican I, Liew CC. Blood gene signature for early hepatocellular carcinoma detection in patients with chronic hepatitis B. J Clin Gastroenterol. 2015 Feb;49(2):150-7. doi: 10.1097/MCG.0000000000000112. PMID: 25569223.
 
Colorectal Cancer (See ColonSentry References)
 
Crohn’s and Ulcerative Colitis

Burakoff R, Hande S, Ma J, Banks PA, Friedman S, Makrauer F, Liew CC. Differential regulation of peripheral leukocyte genes in patients with active Crohn's disease and Crohn's disease in remission. J Clin Gastroenterol. 2010 Feb;44(2):120-6. doi: 10.1097/MCG.0b013e3181a9ef53. PMID: 19826276.

Burakoff R, Chao S, Perencevich M, Ying J, Friedman S, Makrauer F, Odze R, Khurana H, Liew CC. Blood-based biomarkers can differentiate ulcerative colitis from Crohn's disease and noninflammatory diarrhea. Inflamm Bowel Dis. 2011 Aug;17(8):1719-25. doi: 10.1002/ibd.21574. Epub 2011 Jan 6. PMID: 21744426.

Barnes EL, Liew CC, Chao S, Burakoff R. Use of blood based biomarkers in the evaluation of Crohn's disease and ulcerative colitis. World J Gastrointest Endosc. 2015 Nov 25;7(17):1233-7. doi: 10.4253/wjge.v7.i17.1233. PMID: 26634038; PMCID: PMC4658602.

Burakoff R, Pabby V, Onyewadume L, Odze R, Adackapara C, Wang W, Friedman S, Hamilton M, Korzenik J, Levine J, Makrauer F, Cheng C, Smith HC, Liew CC, Chao S. Blood-based biomarkers used to predict disease activity in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 2015 May;21(5):1132-40. doi: 10.1097/MIB.0000000000000340. PMID: 25895006.
 
Heart Failure/Cardiovascular Disease

Ma J, Liew CC. Gene profiling identifies secreted protein transcripts from peripheral blood cells in coronary artery disease. J Mol Cell Cardiol. 2003 Aug;35(8):993-8. doi: 10.1016/s0022-2828(03)00179-2. PMID: 12878486.

Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC. Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. Atherosclerosis. 2007 Mar;191(1):63-72. doi: 10.1016/j.atherosclerosis.2006.05.032. Epub 2006 Jun 30. PMID: 16806233.

Liew CC. Expressed genome molecular signatures of heart failure. Clin Chem Lab Med. 2005;43(5):462-9. doi: 10.1515/CCLM.2005.084. PMID: 15899667.

Vanburen P, Ma J, Chao S, Mueller E, Schneider DJ, Liew CC. Blood gene expression signatures associate with heart failure outcomes. Physiol Genomics. 2011 Apr 27;43(8):392-7. doi: 10.1152/physiolgenomics.00175.2010. Epub 2011 Jan 25. PMID: 21266504; PMCID: PMC3092336.
 
Osteoarthritis
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Zhang H, Marshall KW, Tang H, Hwang DM, Lee M, Liew CC. Profiling genes expressed in human fetal cartilage using 13,155 expressed sequence tags. Osteoarthritis Cartilage. 2003 May;11(5):309-19. doi: 10.1016/s1063-4584(03)00032-3. PMID: 12744936.

Marshall KW, Zhang H, Yager TD, Nossova N, Dempsey A, Zheng R, Han M, Tang H, Chao S, Liew CC. Blood-based biomarkers for detecting mild osteoarthritis in the human knee. Osteoarthritis Cartilage. 2005 Oct;13(10):861-71. doi: 10.1016/j.joca.2005.06.002. PMID: 16139532.
 
Schizophrenia/Mental Health
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Tsuang MT, Nossova N, Yager T, Tsuang MM, Guo SC, Shyu KG, Glatt SJ, Liew CC. Assessing the validity of blood-based gene expression profiles for the classification of schizophrenia and bipolar disorder: a preliminary report. Am J Med Genet B Neuropsychiatr Genet. 2005 Feb 5;133B(1):1-5. doi: 10.1002/ajmg.b.30161. PMID: 15645418.

Glatt SJ, Stone WS, Nossova N, Liew CC, Seidman LJ, Tsuang MT. Similarities and differences in peripheral blood gene-expression signatures of individuals with schizophrenia and their first-degree biological relatives. Am J Med Genet B Neuropsychiatr Genet. 2011 Dec;156B(8):869-87. doi: 10.1002/ajmg.b.31239. Epub 2011 Oct 3. PMID: 21972136; PMCID: PMC3213682.

Mellon SH, Wolkowitz OM, Schonemann MD, Epel ES, Rosser R, Burke HB, Mahan L, Reus VI, Stamatiou D, Liew CC, Cole SW. Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment. Transl Psychiatry. 2016 May 24;6(5):e821. doi: 10.1038/tp.2016.79. P
ColonSentry®
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​Han M, Liew CT, Zhang HW, Chao S, Zheng R, Yip KT, Song ZY, Li HM, Geng XP, Zhu LX, Lin JJ, Marshall KW, Liew CC. Novel blood-based, five-gene biomarker set for the detection of colorectal cancer. Clin Cancer Res. 2008 Jan 15;14(2):455-60. doi: 10.1158/1078-0432.CCR-07-1801. Epub 2008 Jan 18. PMID: 18203981.

Marshall W, Chao S, Nossova N, Bao W, Ma J, Mohr S, El Khattabi F, Liew CC. Stratification of colorectal cancer probability using six genes from whole blood. Cancer Res May 1 2008 (68) (9 Supplement) LB-214.

Chin W, Andrew S. The Cost-Effectiveness of a Blood Test For Colorectal Cancer Screening. Canadian Agency for Drugs and Technologies in Health Symposium, April 2009.

Marshall KW, Mohr S, Khettabi FE, Nossova N, Chao S, Bao W, Ma J, Li XJ, Liew CC. A blood-based biomarker panel for stratifying current risk for colorectal cancer. Int J Cancer. 2010 Mar 1;126(5):1177-86. doi: 10.1002/ijc.24910. PMID: 19795455.

Yip KT, Das PK, Suria D, Lim CR, Ng GH, Liew CC. A case-controlled validation study of a blood-based seven-gene biomarker panel for colorectal cancer in Malaysia. J Exp Clin Cancer Res. 2010 Sep 16;29(1):128. doi: 10.1186/1756-9966-29-128. PMID: 20846378; PMCID: PMC2949823.

Chao S, Ying J, Liew G, Marshall W, Liew CC, Burakoff R. Blood RNA biomarker panel detects both left- and right-sided colorectal neoplasms: a case-control study. J Exp Clin Cancer Res. 2013 Jul 23;32(1):44. doi: 10.1186/1756-9966-32-44. PMID: 23876008; PMCID: PMC3734158.

Lim CR, Sim MH, Seow EL, Das PK, Harris DF, Lee MM, Liew CC, Burakoff R. Increasing Colonoscopy Compliance Using a Blood-Based Risk Assessment Test for Colorectal Cancer. Gastroenterology and Hepatology. 2014 Aug 31;1(1):8-10.

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Prostate Health Index
​Improving the Prediction of Pathologic Outcomes in Patients Undergoing Radical Prostatectomy:
The Value of Prostate Cancer Antigen 3 (PCA3), Prostate Health Index (Phi) and Sarcosine


Prognostic accuracy of Prostate Health Index and urinary Prostate Cancer Antigen 3 in predicting pathologic features after radical prostatectomy
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A Multicenter Study of [-2]Pro-Prostate Specific Antigen Combined With Prostate Specific Antigen and Free Prostate Specific Antigen for Prostate Cancer Detection in the 2.0 to 10.0 ng/ml Prostate Specific Antigen Range. Journal of Urology, 2011
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Evaluation of [ − 2] proPSA and Prostate HealthIndex (phi) for the detection of prostate cancer:
a systematic review and meta-analysis
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The Prostate Health Index: a new test for the detection of prostate cancer, Stacy Loeb and William J. Catalona, PHI a New PCa Test Catalona-Loeb 2014
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BreastSentry
​Melander O, Belting M, Manjer J, et al. Validation of plasma proneurotensin as a novel biomarker for the prediction of incident breast cancer. Cancer Epidemiol Biomarkers Prev. 2014 Aug;23(8):1672-6.

Melander O, Orho-Melander M, Manjer J, et al. Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk. J Clin Oncol. 2015 Aug 20;33(24):2632-8

Dupouy S, Mourra N, Doan VK, et al. The potential use of the neurotensin high affinity receptor 1 as a biomarker for cancer progression and as a component of personalized medicine in selective cancers. Biochimie 2011;93:1369–78

Melander O, Maisel AS, Almgren P, et al. Plasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality. JAMA 2012;308:1469–75.
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StageZero Life Sciences. Ltd.
​30-70 East Beaver Creek Road
Richmond Hill, Ontario L4B 3B2

StageZero Life Sciences, Inc.
​8751 Park Central Drive, Suite 200
Richmond, VA 23227
​TEL: 855.420.7140 
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  • About
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