The Sentinel Principle® |
The Scientific Observation that Circulating Blood Reflects,
in a Detectable Way, What is Occurring Throughout the Body. |
The Sentinel Principle® |
The Scientific Observation that Circulating Blood Reflects,
in a Detectable Way, What is Occurring Throughout the Body. |
Small, Subtle Changes in Your Messenger RNA (mRNA) Can Identify Cancer Early - And We've Developed the Science that Finds Them
Most people think of cancer as changes, or mutations, in the sequence of DNA that lead to uncontrolled cell division. However, in between DNA and proteins (your cell's building blocks) is another layer of information called messenger RNA (mRNA) and it is a crucial link to finding cancer. Changes in mRNA expression can be measured in blood and serve as specific early cancer indicators for cancer and other diseases. StageZero Life Sciences discovered this principle, named it the Sentinel Principle®, and patented the technology platform behind it. The Sentinel Principle has already been used to develop the first liquid biopsy for Colorectal Cancer (ColonSentry®) and is the foundation of Aristotle® - our next generation test for multiple cancers.
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The Sentinel Principle®, a platform technology developed by StageZero Life Sciences, is based on the concept that all clinical conditions and body states, including those resulting from disease or in response to treatment, generate characteristic gene expression signatures in the blood.
One of the strengths of the Sentinel Principle is its flexibility. Applying it to different disease areas enables our scientists to generate specific combinations of biomarkers for numerous applications and medical conditions. This enables us to provide consultation to patients and clinicians on the presence of molecular biomarkers and their reflection of disease activity, and allows us to focus on the clinical questions and diseases with the greatest unmet need and largest opportunities to improve care. |
StageZero Life Sciences. Ltd.
30-70 East Beaver Creek Road Richmond Hill, Ontario L4B 3B2 |
StageZero Life Sciences, Inc.
8751 Park Central Drive, Suite 200 Richmond, VA 23227 TEL: 855.420.7140 Contact Information |